Orofacial Central Hypersensitivity Syndromes

The significant advances in scientific knowledge that Medicine and other health disciplines have experienced, especially since the late nineteenth century, has improved medical and surgical treatments for diseases that have historically most seriously threatened humanity (childhood diseases, respiratory and gastrointestinal infectious diseases, cardiovascular diseases, cancer).

This fact has led to a rapid increase in population and a shift in the population pyramid towards older ages, which has favored the emergence of new clinical entities that, while not fatal, have in common a multifactorial etiopathogenesis and pathophysiology (genetics/epigenetics, hormones, stress, dietary … ), its long duration, the absence of analytical data or image valid to assist us in the diagnosis and the lack of curative treatment, allowing only to apply models of palliative and symptomatic therapeutic management. Many of these chemical entities have a common origin in a loss of functional equilibrium of the PsychoNeuroEndocrinImmune Axis (PNEI) that alters the state of homeostasis and leads to pathology.