The popularity of neural blockade as a diagnostic and therapeutic tool in painful conditions is predicated upon several features of chronic pain. The complexity of chronic pain is based on social, emotional, financial, and legal factors and orofacial pain also presents specific diagnostic challenges. Diagnostic blocks aim to determine the pathophysiology of clinical pain, the site of nociception, and the pathway of afferent neural signals and information gained from blocks may then be applied to the choice of medicines, therapeutic blocks, or surgical therapy, and may also be used to anticipate the response to neuroablative therapies. The diagnostic use of neural blockade rests on three premises. First, pathology causing pain is located in an exact peripheral location, and impulses from this site travel via a unique and consistent neural route. Second, injection of local anesthetic totally abolishes sensory function of intended nerves and does not affect other nerves. Third, relief of pain after local anesthetic block is attributable solely to block of the target afferent neural pathway. The validity of these assumptions is limited by complexities of anatomy, physiology, and psychology of pain perception and the effect of local anesthetics on impulse conduction. These assumptions are flawed and evidence base for many diagnostic and subsequent therapeutic is scarce.Therapeutic nerve blocks can be delivered for various orofacial pain conditions. Patient variables may include age (availability of other analgesic modalities), medical comorbidities, pain history (refractory or constant), consistency of and size of region affected and pathophysiology of heir pain condition. Block protocols may vary including; region of injection (cervical N, trigeminal N, etc), site (peripheral, central blocks or epithelial or subepithelial), agent type (Non-ablative; local anaesthesia, steroid, Botox, saline, dry needling. Or ablative glycerol or alcohol), agent volume, agent concentration, guided or non-guided, single or repeated. Overall evidence is not at high level for most block interventions for various types of orofacial pain conditions with the exception of Botox for migraines. This presentation will aim to provide the delegate with an overview of the various types of available block interventions for orofacial pain, their limitations and the related evidence base. Guidelines for the case selection, application and assessment of the block intervention will also be highlighted.